Interfering with the interaction between ErbB1, nucleolin and Ras as a potential treatment for glioblastoma
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چکیده
منابع مشابه
Interfering with the interaction between ErbB1, nucleolin and Ras as a potential treatment for glioblastoma
The three oncogenes, ErbB receptors, Ras proteins and nucleolin may contribute to malignant transformation. Previously, we demonstrated that nucleolin could bind both Ras protein and ErbB receptors. We also showed that the crosstalk between the three proteins facilitates anchorage independent growth and tumor growth in nude mice, and that inhibition of this interaction in prostate and colon can...
متن کاملOncogenic synergism between ErbB1, nucleolin, and mutant Ras.
Alterations in the ErbB family of growth factor receptors, their signaling components, and mutational activation of Ras proteins are major contributors to malignant transformation. Recently, mutant Ras was shown to be capable of activating ErbB receptors in a ligand-independent manner. Furthermore, it was observed that nucleolin, a transcriptional regulator and ribosome biogenesis factor, can b...
متن کاملMolecular and Cellular Pathobiology Oncogenic Synergism between ErbB1, Nucleolin, and Mutant Ras
Alterations in the ErbB family of growth factor receptors, their signaling components, and mutational activation of Ras proteins are major contributors to malignant transformation. Recently, mutant Ras was shown to be capable of activating ErbB receptors in a ligand-independent manner. Furthermore, it was observed that nucleolin, a transcriptional regulator and ribosome biogenesis factor, can b...
متن کاملBreaking the malignant triangle in glioblastoma - ErbB1/nucleoin/Ras
Glioblastoma is one of the most malignant tumors in humans, with poor diagnosis and a low survival rate. These tumors overexpress the ErbB1 receptor and have high levels of cell surface nucleolin, which serves as an indicator for disease grade. We have previously identified a crosstalk between three oncogenes: ErbB1, Ras and nucleolin. This lead us to suggest a combined treatment using FTS, to ...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2014
ISSN: 1949-2553
DOI: 10.18632/oncotarget.2343